Cooking Pork Tenderloin in Oven at 375o

Pork tenderloin is one of the best portions of pork meat and one of the cheapest pork meats. For that reason, pork tenderloin is a standard meat option for many. But preparing a pork tenderloin requires a certain degree of finesse, and your oven prep can make or break your dish. Cooking pork tenderloin in oven at 375o is one of the best way of cooking the dish.

The standard oven temperature regarding pork tenderloin is around 375o, and to get the most out of your pork tenderloin, and you need to keep it in the oven for a precise amount of time.

And that’s why you need to know how long to cook pork tenderloin in an oven at 375o, and in this article, we’ll break down everything you need to know regarding cooking pork tenderloin.

What is A Pork Tenderloin? 

Pork tenderloin is one of the tenders and the leanest cut of pork meat. It is also referred to as the gentleman’s cut or pork fillet. This long boneless meat contains very little fat; thus, the cooking heat needs to be generous yet controlled at the time.

This meat is exquisite because it is located around the spine and doesn’t endure much stress or movement, thus remaining very tender. And as it is longer in size and wights around 1 pound, this type of pork meat is best suited for intimate gatherings.

If we look for the competition for this meat, the only competitor that comes to mind is beef’s filet mignon. So that should give you an idea of how tender and desired this portion of meat is.

Why is Proper Heat Control Important for Pork Tenderloin?

Keeping any sort of meat tender and medium-rare is one of the most challenging tasks any cook can ever face, including professionals. But when it comes to pork tenderloins, this difficulty level goes straight up to the moon as a bit of calculation error, and you might end up with an overcooked or undercooked pork tenderloin, and that is not acceptable anywhere in the world.

This happens because the meat is so tender and thin, and at the same time, it is 95% meat, so there’s close to no fat here that can take the extra heat and keep the flavours tucked in. And you can make use of a slow cooker as pork meats generally get dried up very fast. 

So, as you can’t have these options to ensure that you can cook your pork tenderloin the best way possible so that it can maintain its tenderness and flavours, you cannot but go with proper meat preparation, perfect timing and heat management when cooking pork tenderloin,

And that’s why you need to know how long you should put the pork tenderloin in the oven at 375o F.

How Long Should You Cook Pork Tenderloin at 375o?

To be exact, it takes from somewhere between 30 to 45 minutes regarding how you dressed and seasoned the pork tenderloin. But this is as simple as it sounds because you need to consider a lot of factors & decisions that come into play when cooking pork tenderloin at 375o F.

Silver-skin Removal

Silverskin or a small sinew around the pork tenderloin gets tricky when they are cooked. So, if they are not removed beforehand, they’ll consume a large portion of the heat, leading you to a misbelief that your pork tenderloin is cooked, but in reality, the silver skin just got tough while the original meat is still undercooked. 

Pork tenderloin is one of the best meat portions globally, and only perfect cooking can give the pork tenderloin the value it deserves. We hope that from this article you’ve found the answer regarding how long to cook pork tenderloin in Oven at 375o.

So, depending on whether or not the silver skin is removed, the duration of heating the pork tenderloin will change. It is ideal for removing the silver skin as it also hampers when you want to bring out the maximum flavour of the meat.

Brine Vs Marinate

Depending on your preference, you can either go with bringing your pork tenderloin or marinating it. And this also affects the cooking time in the oven for the pork tenderloin because marinating provides flavouring on the meat's exterior.

On the other hand, when you are bringing the pork tenderloin, the salt involved penetrates the meat and turns the heart more juicer, and the meat takes a little more time to cook because not it is going to bring out more juice and increase the flavour. So, it’s better to go with brine as maximum flavour output is all you should look for.


Pork tenderloin being thin-layered is one side is a little bit thicker than the other. So, when you put it out in the oven, one side gets dry while the other gets overcooked; to avoid that, you need to avoid that; otherwise, your meat will spend more time in the oven than required. 

An easy solution is putting the thinner meats into a skewer to match the thickness on the other sides and the overall pork tenderloin.   


This part depends on whether you went with the bringing route or not. If you brined your pork tenderloin, then a light seasoning will do for you. But if you didn’t, it will require a good amount of seasoning and the heavier the seasoning, and the more time is needed in the cooking oven.

Final Verdict

So, if we sum all of the factors in, we can see that you need to consider a lot of things to conclude the exact time that a pork tenderloin should be kept in the cooking oven.

If you want to keep the temperature to 375o then if you remove the silver skin and brine it properly while managing the thickness with a soft touch of slight seasoning, you need to keep your pork tenderloin in the oven from 37 minutes to 40 minutes at max.


Pork tenderloin is one of the best meat portions globally, and only perfect cooking can give the pork tenderloin the value it deserves. We hope that from this article you’ve found the answer regarding how long to cook pork tenderloin in Oven at 375o.

So, what are you waiting for? Go out there and make the best pork tenderloin you can make!

You Can Also Read: Best George Foreman Grills